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The inhibitors of threeα-hydroxysteroid dehydrogenase, 0231A and 0231B, were extracted in 2001 by Gräafe from the fermentation broth of Streptomyces sp. HKI0231. Meanwhile threeα-hydroxysteroid dehydrogenase can be an enzyme associated with inflammatory procedures, these compounds are favorable as key structures for anti-inflammatory agents.387

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fifty one nM. Such finding points out the outstanding position of methylene linker integrated amongst the terminal phenyl and substituted piperazine in enhancing BCR-ABLWT inhibition, which may stem from the flexibility of prolonged piperazine moiety to sort restricted interactions with the allosteric website of ABL. The NZhang et al. [eighty one

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